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综述了蛋白酶抑制剂对苏云金杆菌晶体毒素(B.t.Cry)活性影响的最新研究进展。蛋白酶抑制剂降低中肠中蛋白酶活性,这不仅影响B.t.Cry原毒素的活化,而且延缓B.t.Cry毒素的水解失活。蛋白酶抑制剂对B.t.Cry毒素协同作用取决于这2种作用的均衡。
The latest research progress on the effects of protease inhibitors on B.t.Cry activity was reviewed. Protease inhibitors reduce protease activity in the midgut, which not only affects the activation of B.t.Cry protoxins, but also delays the hydrolytic inactivation of B.t.Cry toxins. The synergistic effect of protease inhibitors on B.t.Cry toxin depends on the balance of these two effects.