树突状细胞(DC)是初始T细胞的惟一启动者,主要通过三类信号调整效应T细胞的分化。作为免疫调控的关键因素之一,DC对促进多发性硬化(MS)的发病具有重要作用。本文综述了MS中枢神经系统中致病性DC的特点,各型MS外周DC的异常变化,以及DC在诱导实验性变态反应性脑脊髓炎中的作用。 Dendritic cells (DCs) are the only initiators of naive T cells that regulate effector T cell differentiation primarily through three types of signals. As one of the key factors in immune regulation, DC plays an important role in promoting the development of multiple sclerosis (MS). This article reviews the characteristics of pathogenic DCs in the central nervous system of MS, the abnormal changes of peripheral DCs in various types of MS, and the role of DCs in inducing experimental allergic encephalomyelitis.