抗-HBs和抗-HBc的出现是HBV感染缓解的一种常见免疫现象。但有时放射免疫法(RIA)亦可能不易测出血清中这两种标志物。尽管慢性肝炎病人缺乏循环HBV标记物,但其肝内却可检出整合的HBV DNA。作者推测,曾感染HBV但血清中缺乏HBV标志的病人,接种单剂HBV疫苗能引起抗-HBs快速升高的回忆反应。为了研究尚未确定病原 The emergence of anti-HBs and anti-HBc is a common immune phenomenon of HBV infection relief. But sometimes radioimmunoassay (RIA) may not be easy to measure these two markers in serum. Although chronic hepatitis patients lack circulating HBV markers, integrated HBV DNA can be detected in the liver. The authors hypothesized that in patients who had been infected with HBV but lacking HBV markers in their serum, vaccination with a single dose of the HBV vaccine elicited a recall response that was rapidly escalating anti-HBs. In order to study yet undetermined pathogen