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晚近意大利Scardi等以多次蹬车试验(Radwood方案)引起中度心绞痛和ST段压低≥2mm的运动时间稳定(相差不超过15%)的冠心病患者为对象,进行双盲随机试验.试验前停用β阻滞剂、钙拮抗剂和长效硝酸酯至少3天.第一天早晨7时起使用第一块贴片24小时,然后剥去贴片停药24小时.按此方式使用第二、第三块贴片.同一受试者采用的三块贴片中一块不含硝酸甘油,另二块在24小时内分别给予硝酸甘油10mg、20mg,作为自身对照.硝酸甘油贴敷后第4、第24小时的卧位和立位收缩压、立位心率均显著增高(即达到有效血药浓度),
Recently, Scardi et al performed a double-blind randomized trial of coronary heart disease patients with multiple angst tests (Radwood regimen) and patients with moderate angina pectoris and stable ST segment depression ≥2 mm (difference of not more than 15%), Stop using beta blockers, calcium antagonists, and long-acting nitrates for at least 3 days Use the first patch for 24 hours on the first day at 7 am and strip the patch for 24 hours Use this method using Second, the third patch .Three pieces of the same subject used in a piece of nitroglycerin-free, the other two were given within 24 hours of nitroglycerin 10mg, 20mg, as their own control. Nitroglycerin after the first 4, the first 24 hours of lying and standing systolic blood pressure, standing heart rate were significantly higher (that is, to achieve effective plasma concentration)