随着分子生物学及功能性研究的不断进展,遗传性心律失常的病因逐渐明晰,心脏离子通道或调节蛋白的基因突变已经在遗传决定的多形性室性心动过速如长QT综合征、B rugada综合征、短QT综合征和儿茶酚胺源性多形性室性心动过速中被证实,现就这些综合征的遗传学基础、临床特征和目前的治疗作一回顾。 With the continuous progress of molecular biology and functional studies, the etiology of hereditary arrhythmia gradually clear, genetic mutations in cardiac ion channels or regulatory proteins have been in the genetic polymorphism of ventricular tachycardia such as long QT syndrome, B rugada syndrome, short QT syndrome and catecholaminergic ventricular tachycardia were confirmed, the genetic basis of these syndromes, clinical features and current treatment are reviewed.