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药物治疗仍是防治疟疾的主要手段,但用于临床的抗疟药中,仅伯氨喹具有杀伤配子体的作用。已证实咯萘啶对疟原虫红内期裂殖体有较强的杀伤作用,而且,有研究表明该药能使疟原虫超微结构发生变化;能抑制恶性疟原虫DNA拓朴异构酶Ⅱ的活性,但其抗疟作用的机制仍不清楚。本文报告了咯萘啶和几种DNA拓朴异构酶Ⅱ抑制剂对培养的多种药物抗性恶性疟原虫配子体的杀伤作用的研究结果。
Medication remains the mainstay of malaria control, but only primaquine plays a role in killing gametocytes in clinical antimalarials. It has been confirmed that pyronaridine has a strong killing effect on the red blood cell stage of Plasmodium. Moreover, some studies have shown that the drug can change the ultrastructure of Plasmodium, and can inhibit the DNA topoisomerase II activity of Plasmodium falciparum , But the mechanism of its anti-malarial effect remains unclear. This paper reports the results of studies on the killing effect of pyronaridine and several DNA topoisomerase II inhibitors on cultured multidrug-resistant Plasmodium falciparum gametocytes.