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目的研究乳腺癌患者手术治疗前后血清CD46水平检测及临床意义。方法应用ELISA法对58例乳腺癌患者(实验组)进行手术治疗前后CD46水平的检测,并与30例正常对照组进行对比。结果实验组术前血清CD46显著高于对照组,术后CD46水平较术前显著下降(P<0.05)。术后复发患者术前及术后CD46变化差值显著高于非复发组,并与患者无病生存期呈正相关(r=0.57,P<0.05)。结论检测乳腺癌患者手术前后血清CD46水平变化可作为诊断及预后的预测参数。
Objective To study the serum CD46 level before and after breast cancer surgery and its clinical significance. Methods The CD46 levels of 58 breast cancer patients (experimental group) before and after operation were detected by ELISA, and compared with 30 normal control group. Results The preoperative serum CD46 in the experimental group was significantly higher than that in the control group, and the postoperative CD46 level was significantly lower than that before the operation (P <0.05). The difference of CD46 before and after operation in patients with postoperative recurrence was significantly higher than that in non-recurrence patients and was positively correlated with disease-free survival (r = 0.57, P <0.05). Conclusion The detection of serum CD46 levels in patients with breast cancer before and after surgery can be used as a prognostic parameter in diagnosis and prognosis.