论文部分内容阅读
目的对中西医结合治疗都市白领骨质疏松症的临床疗效及安全性进行探讨。方法选取2014年1月—2015年1月东阳市人民医院收治的112例骨质疏松患者,将其按照随机数字法分为观察组和对照组,每组56例,对照组采用常规西医(阿伦磷酸钠片)治疗,观察组在对照组基础上结合中药补肾健骨汤治疗,2组患者均治疗3个月后评价疗效。结果治疗3个月后观察组总有效率为96.4%,显著高于对照组的76.8%(χ2=9.314,P<0.05)。治疗3个月2组中医症状总积分均较治疗前显著下降(均P<0.05),但观察组下降更为明显(P<0.05)。治疗3个月2组腰椎L2~4骨密度均较治疗前显著上升(均P<0.05),但观察组上升更为明显(P<0.05)。治疗3个月2组骨转换生化标志物均较治疗前显著下降(均P<0.05),但观察组下降更为明显(P<0.05)。2组患者治疗期间肝、肾功能均在正常范围内,2组不良反应主要为胃肠道反应,对症处理后均可耐受,未出现停药现象。结论阿伦磷酸钠片联合补肾健骨汤治疗骨质疏松症临床疗效好,安全性高,值得临床推广。
Objective To explore the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of urban white-collar osteoporosis. Methods One hundred and twelve patients with osteoporosis who were admitted to Dongyang People’s Hospital from January 2014 to January 2015 were randomly divided into observation group and control group, 56 cases in each group. The control group was treated with routine western medicine Sodium phosphate tablets) treatment, the observation group on the basis of the control group with traditional Chinese medicine Bushenjiangyu Tang treatment, two groups of patients were treated for 3 months after the evaluation of the curative effect. Results After 3 months of treatment, the total effective rate in the observation group was 96.4%, significantly higher than 76.8% in the control group (χ2 = 9.314, P <0.05). The total score of TCM symptoms in the two groups after 3 months of treatment was significantly lower than that before treatment (all P <0.05), but the decrease in the observation group was more obvious (P <0.05). The BMD of L2 ~ 4 in lumbar spine of two groups after treatment for 3 months increased significantly (all P <0.05), but the observation group increased more obviously (P <0.05). After 3 months of treatment, the biochemical markers of bone turnover were significantly decreased in both groups (all P <0.05), but the decrease in the observation group was more obvious (P <0.05). The liver and kidney functions of the two groups were within the normal range during the treatment. The two groups of adverse reactions were mainly gastrointestinal reactions, which were tolerable after symptomatic treatment, and no withdrawal was observed. Conclusion Allegoric sodium tablets combined with Bushenjiangyu Decoction in the treatment of osteoporosis clinical efficacy, high safety, it is worth clinical promotion.