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目的 :探讨抗心肌 β 肾上腺素能受体 (简称 β 受体 )抗体对小儿心脏病的诊断价值。 方法 :运用免疫印转法检测了 30例病毒性心肌炎 (VMC) ,14例扩张型心肌病 (DCM) ,2 2例先天性心脏病 (CHD) ,10例风湿性心脏病(RHD)患儿和 2 5例正常对照组 (NC)血浆抗 β 受体抗体水平。 结果 :VMC和DCM患儿中抗 β 受体抗体的阳性率显著高于CHD、RHD和NC组 (P <0 .0 1)。抗 β 受体抗体诊断VMC和DCM的灵敏度为 80 % ,特异度为 98%。 结论 :小儿心脏病的鉴别诊断中抗 β 受体抗体的测定有重要价值 ,可作为小儿VMC和DCM的特异性诊断指标
Objective: To investigate the diagnostic value of anti-myocardial β adrenergic receptor (beta receptor) antibody in children with heart disease. Methods: 30 cases of viral myocarditis (VMC), 14 cases of dilated cardiomyopathy (DCM), 22 cases of congenital heart disease (CHD) and 10 cases of rheumatic heart disease (RHD) were detected by immunoblotting. And 25 normal controls (NC) plasma anti-β -receptor antibody levels. Results: The positive rate of anti-beta -receptor antibody in VMC and DCM children was significantly higher than that in CHD, RHD and NC groups (P <0.01). Anti-beta receptor antibodies have a sensitivity of 80% and a specificity of 98% for VMC and DCM. Conclusion: The determination of anti-beta -receptor antibody in the differential diagnosis of pediatric heart disease is of great value and can be used as a specific diagnostic indicator for pediatric VMC and DCM