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非典型畸胎样/横纹肌样瘤(AT/RT)是中枢神经系统罕见的侵袭性肿瘤,好发于儿童。成人AT/RT临床罕见,主要发生于鞍区。有文献报道12例鞍区AT/RT均发生于成年女性,提示成人AT/RT与儿童普通型AT/RT生物学不同。作者报道6例鞍区AT/RT的形态学特征、INI1/SMARCB1基因状态及临床特点。6例患者均为成年女性,年龄21~69岁。肿瘤组织学特点为致密的、弥漫增生的混
Atypical teratoid / rhabdomyosarcoma (AT / RT) is a rare invasive tumor of the central nervous system that occurs in children. Adult AT / RT clinical rare, mainly occurs in the saddle area. It has been reported in the literature 12 cases of saddle area AT / RT occurred in adult women, suggesting that adult AT / RT and general children AT / RT biology is different. The authors report the morphological features of AT / RT in 6 cases and the status and clinical features of INI1 / SMARCB1. All 6 patients were female and were 21 to 69 years old. Tumor histology is characterized by dense, diffuse proliferation of mixed