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目的以慢性毒性试验研究人参对Wistar大鼠血液学指标的影响。方法 80只健康清洁级Wistar大鼠,选取人参粉末作为受试物,设0、5.0、6.5、8.0 g/kg BW 4个剂量组,每组20只大鼠,雌雄各半,在试验末期(181 d)分别检测大鼠血液学指标。结果试验末期(181 d)大鼠细胞学指标检测结果显示,5.0、6.5、8.0 g/kg BW剂量组试验大鼠血红蛋白(Hb)、红细胞(RBC)、白细胞(WBC)计数及淋巴细胞(LYMP)、单核细胞(MONO)、嗜中性细胞(NEUT)、嗜酸性细胞(EO)、嗜碱性细胞(BASO)百分比与0 g/kg BW剂量组试验大鼠比较,差异均无统计学意义(P>0.05)。结论在180 d慢性毒性试验中,食用人参未对大鼠血液学指标产生明显影响。
Objective To study the effects of ginseng on the hematological parameters of Wistar rats by chronic toxicity test. Methods Eighty healthy and clean Wistar rats were randomly divided into 4 groups: 0, 5.0, 6.5 and 8.0 g / kg BW, 20 rats in each group, half male and half female. At the end of the experiment 181 d) were tested for hematological parameters in rats. Results The results of rat cytology test at the end of the experiment (181 d) showed that the levels of hemoglobin (Hb), erythrocytes (RBC), white blood cells (WBC) and lymphocytes (LYMP ), Monocyte (MONO), neutrophil (NEUT), eosinophil (EO), basophil (BASO) percentage compared with 0 g / kg BW dose group of rats, the difference was not statistically significant Significance (P> 0.05). Conclusion In the chronic toxicity test of 180 days, ginseng did not have significant effect on hematological indexes in rats.