【摘 要】
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Dear Editor,Dysregulation of hepatic lipid and glucose production results in obesity,diabetes and nonalcoholic fatty liver disease.De novo lipogenesis and gluco
【机 构】
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MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Scien
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Dear Editor,Dysregulation of hepatic lipid and glucose production results in obesity,diabetes and nonalcoholic fatty liver disease.De novo lipogenesis and gluconeogenesis in the liver contribute,at least in part,to the dynamic homeostasis of lipid and glucose levels (Rui,2014;Han and Wang,2017).These processes are regulated at the transcriptional level by different transcription factors in response to various environmental cues,including hormones,nutrition and stress.Regulators of lipogenesis include the sterol regulatory element-binding proteins (SREBPs),which are members of the basic helix-loop-helix leucine zipper transcription factor family (Goldstein et al.,2006).
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