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目的：分析抗结核药物致超敏反应综合征(DHS)的临床特点。方法回顾性分析天津市海河医院结核科2012年6月~2014年8月住院患者中确诊的5例抗结核药物致超敏反应综合征(DHS)的病例资料,归纳其临床特点,总结抗结核药物致DHS的发病规律。结果5例患者中男3例,女2例。发病年龄18~47岁。5例患者于用药后15~60 d出现皮疹伴发热,2例出现淋巴结肿大,3例患者出现面部肿胀,5例患者均有不同程度嗜酸粒细胞升高,肝功能损害。5例患者均予糖皮质激素治疗,保肝对症支持治疗,4例好转出院,1例转院。结论抗结核药物致超敏反应病情复杂,早期发现早期治疗效果良好。“,”Objective To characterize the clinical characteristics of drug hypersensitivity syndrome(DHS) caused by anti-TB medicine.Methods Retrospectively analysis the clinical characteristics of 5DHS caused by anti-TB medicine Patients admit ed into Tianjin hai he hospital duri ng June 2012 t o A2014.And the occurrence pat erns of DHS were summarized.Results There were 3 males and 2 females with anage rangeof 18 to 47 years.A1l cases developedskin rashes with fever within 15 to 60 days (n=5).Lymphadenopathy was observed (n=2), facial swel ing Was also appeared (n=3). Eosinophilia Was observed in al cases (n=5).Liver involvement was common (n=5).Glucocorticoids were applied in al cases (n=5).The clinical outcomes included discharging with recovery (n=4),and transfer to another hospital(n=1).Conclusion The clinical manifestations of DHS caused by anti-TB medicine are complicated.IF early detection and treatment with good results.