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目的:观察中药内外兼治配合依那西普治疗类风湿性关节炎(RA)的疗效及安全性。方法:57例随机分为治疗组25例和对照组32例。对照组应用依那西普,每次剂量为25mg,皮下注射,每周2次;治疗组在对照组治疗的基础上采用口服中药配合外敷中药疗法。两组疗程均为6个月。治疗前后监测临床疗效指标的变化及药物的不良反应。结果:治疗组总有效率显著高于对照组(P<0.05);在关节疼痛数、关节压痛积分、关节肿胀积分、晨僵时间及20m步行时间等方面均与用药前比较有显著改善(P<0.05或P<0.01);治疗组不良反应发生率显著低于对照组(P<0.05)。结论:中药内外兼治配合依那西普治疗RA疗效优于单用依那西普,且不良反应少而轻微,安全性好。
Objective: To observe the curative effect and safety of treating both rheumatoid arthritis (RA) and traditional Chinese medicine (TCM) concurrently with etanercept. Methods: Fifty-seven cases were randomly divided into treatment group (n = 25) and control group (n = 32). The control group was given etanercept with the dosage of 25mg per subcutaneous injection twice a week. The treatment group was treated with oral Chinese medicine and external application of traditional Chinese medicine on the basis of the control group. Two courses of treatment are 6 months. Monitoring before and after treatment of clinical efficacy indicators of changes and adverse drug reactions. Results: The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). There was a significant improvement in the joint pain count, joint tenderness score, joint swelling score, morning stiffness time and walking time of 20m <0.05 or P <0.01). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P <0.05). Conclusion: The curative effect of traditional Chinese medicine plus etanercept on RA is better than that of etanercept alone, and the side effects are less and minor, and the safety is good.