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本文应用光镜及免疫组织化学技术对煤焦沥青烟气诱发的大鼠肺癌的异质性进行了观察。结果：光镜下，２４例肺癌中由一种以上肿瘤细胞类型构成的异质性肿瘤有９例。ＣＫ、ＥＭＡ及ＮＳＥ抗体的免疫组化染色观察，２例类癌ＥＭＡ和ＮＳＥ均为阳性，１例类癌ＣＫ和ＮＳＥ均为阳性，５例鳞癌和１例类癌ＣＫ、ＥＭＡ和ＮＳＥ均为阳性。提示鳞癌和类癌既表达上皮性分化的标志物，又表达神经内分泌分化标志物。光镜下还观察到鳞癌、腺癌和类癌与支气管粘膜上皮之间有移行过度现象。结果支持“所有类型的肺癌均可能来自多潜能分化的支气管粘膜上皮干细胞”的观点。
In this paper, light microscope and immunohistochemical techniques were used to observe the heterogeneity of rat lung cancer induced by coal tar pitch smoke. RESULTS: Under light microscope, there were 9 cases of heterogeneous tumors consisting of more than one type of tumor cell in 24 cases of lung cancer. Immunohistochemical staining for CK, EMA, and NSE antibodies showed that both EMA and NSE were positive in carcinoid tumors, CK and NSE were positive in one case, and CK, EMA, and NSE in 5 cases of squamous cell carcinoma and 1 case of carcinoid tumors. Positive. It is suggested that squamous cell carcinomas and carcinoids express both epithelial differentiation markers and neuroendocrine differentiation markers. Under the light microscope, excessive migration between squamous cell carcinoma, adenocarcinoma, and carcinoid and bronchial mucosal epithelium was also observed. The results support the view that “all types of lung cancer may come from pluripotently differentiated bronchial epithelial stem cells.”