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目的分析生殖道支原体和衣原体感染对精液质量影响与男性不育的关系。方法选取126例男性不育患者及65名已生育健康男性分别作为观察组、对照组,采用PCR基因扩增法检测所有研究对象尿道分泌物的支原体和衣原体,结合计算机辅助精液分析系统、人工精液分析方法检测所有研究对象的精液质量;对比分析观察组与对照组的支原体、衣原体感染率及精液质量。结果观察组支原体感染率为46.03%、衣原体感染率为23.02%、支原体混合衣原体感染率为7.94%,支原体或衣原体感染率76.99%;对照组支原体感染率为6.15%、衣原体感染率为0、支原体混合衣原体感染率为0,支原体或衣原体感染率6.15%,差异有统计学意义(P<0.05)。支原体感染组与衣原体感染组的精液液化时间、精子活率、精子浓度、正常形态率差异均无统计学意义(P>0.05),与对照组对比,差异有统计学意义(P<0.05)。结论在男性不育患者中生殖道支原体和衣原体感染率较高,导致精液质量参数异常,作为影响精液质量的重要因素,可能增大男性不育发生的风险。
Objective To analyze the relationship between spermatozoal mycoplasma and chlamydia infection on sperm quality and male infertility. Methods 126 cases of male infertility and 65 healthy reproductive men were selected as the observation group and the control group respectively. All patients were tested for urethral secretions of Mycoplasma and Chlamydia by polymerase chain reaction (PCR), and combined with computer-aided semen analysis system, artificial semen Analytical methods were used to measure semen quality of all subjects. Contrast analysis was made between mycoplasma and chlamydia infection rates and semen quality in observation group and control group. Results The infection rate of mycoplasma in the observation group was 46.03%, the infection rate of chlamydia was 23.02%, the infection rate of mycoplasma mixed with chlamydia was 7.94%, the infection rate of mycoplasma or chlamydia was 76.99%, that of control group was 6.15%, the infection rate of chlamydia was 0, The infection rate of mixed chlamydia was 0, and the infection rate of mycoplasma or chlamydia was 6.15%, the difference was statistically significant (P <0.05). There was no significant difference in sperm liquefaction time, sperm motility, sperm concentration and normal morphology between mycoplasma infection and chlamydial infection groups (P> 0.05), but the difference was statistically significant (P <0.05). Conclusions The infection rate of Mycoplasma genitalium and Chlamydia in male infertility patients is high, leading to abnormal semen quality parameters, which may increase the risk of male infertility as an important factor affecting semen quality.