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目的:研制萘普生钠缓释片剂。方法:采用硬脂酸包裹和水凝胶缓释技术及UV测定法,研究了奈普生钠骨架型缓释片剂。结果:缓释片释放度试验结果表明本品缓释效果明显,12h内药物释放曲线符合Higuchi方程(Q=31.46t~(1/2)-7.91 r=0.9947)。结论:本方法较适合于大剂量、易溶性药物缓释制剂的制备。
Objective: To develop naproxen sodium sustained-release tablets. Methods: Naproxen sodium matrix sustained-release tablets were studied by stearic acid-coated and hydrogel sustained-release technique and UV determination. Results: The sustained release tablets release test results show that the slow release effect of this product is obvious, 12h drug release curve in line Higuchi equation (Q = 31.46t ~ (1/2) -7.91 r = 0.9947). Conclusion: This method is suitable for the preparation of high-dose, easily-soluble drug sustained-release preparations.