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目的:促进韦格纳肉芽肿的早期诊断和治疗,提高患者的生存率。方法:回顾性分析我院收治的1例韦格纳肉芽肿患者的发病诊治过程的临床资料并结合文献进行复习。结果:入院后行胸部CT、抗中性粒细胞胞浆抗体(ANCA)等检查,明确诊断后给予糖皮质激素、细胞毒类药物等治疗后短期缓解,5个月后死亡。结论:韦格纳肉芽肿的临床表现多种多样,诊断困难,实验室检查无特异性,临床上对于多系统受累的疾病应警惕此病,应结合患者临床表现及辅助检查做出早期诊断,及早治疗,从而提高患者的生存率。
Objective: To promote the early diagnosis and treatment of Wegener’s granulomatosis and improve the survival rate of patients. Methods: A retrospective analysis of clinical data of one case of Wegener’s granulomatosis admitted to our hospital during the diagnosis and treatment was made and reviewed with literature review. Results: After admission, chest CT and anti-neutrophil cytoplasmic antibody (ANCA) were performed. After definite diagnosis, corticosteroids and cytotoxic drugs were given for short-term relief and died after 5 months. Conclusion: The clinical manifestations of Wegener ’s granulomatosis are diverse and difficult to diagnose. There is no specific laboratory test. Clinically, the disease should be vigilant for the diseases that involve in multiple systems. Early diagnosis should be made according to the clinical manifestations and the auxiliary examinations. Early treatment, thereby enhancing the survival rate of patients.