冠心病是一种受遗传和环境等多因素影响的疾病,高密度脂蛋白(HDL)与冠心病危险性呈负相关。已证实HDL每提高1mg,冠心病的危险性可降低2%~3%[1]。胆固醇酯转运蛋白(CETP)介导胆固醇酯(CE)从HDL向富含载脂蛋白B的脂蛋白(ApoB)(极低密度脂蛋白、中密度脂蛋白及低密度脂蛋白)转运, Coronary heart disease is a genetic and environmental factors that affect the disease, high-density lipoprotein (HDL) and coronary heart disease risk was inversely correlated. Has been confirmed that HDL increased 1mg, the risk of coronary heart disease can be reduced by 2% to 3% [1]. Cholesteryl ester transfer protein (CETP) mediates the transport of cholesterol ester (CE) from HDL to apolipoprotein B-rich lipoproteins (ApoB) (very low density lipoprotein, medium density lipoprotein, and low density lipoprotein)