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目的 :了解 3种血清肿瘤标志物在肺癌诊断的应用价值 ,以提高肺癌的诊断率。方法 :应用放射免疫技术 ,测定 6 2例肺癌患者、4 3例肺良性疾病患者和正常对照的血清 CYFRA2 1- 1、NSE、CEA的水平。结果 :肺癌患者组的 3种标志物 CYFRA 2 1- 1、NSE、CEA的水平明显高于肺良性疾病患者组和正常对照组 (P<0 .0 1)。其中 CYFRA2 1- 1、NSE、CEA的灵敏度分别为 6 5 .4 %、2 9.8%、4 8.7% ,但三者联合检测的灵敏度为 94 .3% ,明显优于 3种血清肿瘤标志物的单项测定。结论 :血清 CYFRA2 1- 1、NSE、CEA对肺癌的诊断有价值 ,建议临床工作中采用三者联合检测。
Objective: To understand the value of three serum tumor markers in the diagnosis of lung cancer in order to improve the diagnostic rate of lung cancer. Methods: The levels of serum CYFRA21-1, NSE and CEA in 62 patients with lung cancer, 43 patients with benign pulmonary disease and normal controls were measured by radioimmunoassay. Results: The levels of CYFRA 2 1- 1, NSE and CEA in lung cancer patients were significantly higher than those in patients with benign lung diseases and controls (P <0.01). The sensitivity of CYFRA2 1- 1, NSE and CEA were 65.4%, 29.8% and 47.7%, respectively, but the sensitivity of the three assays was 94.3%, which was significantly better than that of the three serum tumor markers Single measurement. Conclusion: Serum CYFRA2 1- 1, NSE and CEA are valuable in the diagnosis of lung cancer. It is suggested that the combination of the three should be used in clinical practice.