论文部分内容阅读
心肌缺血/再灌注损伤(IRI)是伴随着冠脉再通及缺血心肌再灌注出现的一系列使缺血心肌损伤更加严重的现象。Schultz首次报道了阿片受体兴奋可诱导急性心肌保护作用。近年来,其他学者发现,吗啡对心肌IRI有保护作用,表现为心肌收缩功能改善,梗死面积减小,病死率降低[1]。1 IRI主要机制研究1.1氧自由基增多研究发现[2],黄嘌呤氧化酶(xanthine oxidase,XO)系统是缺血/再灌注时活性氧
Myocardial ischemia / reperfusion injury (IRI) is accompanied by a series of coronary recanalization and ischemic reperfusion myocardial ischemia caused by a more serious phenomenon. Schultz first reported that opioid receptor excitability induces acute cardioprotection. In recent years, other scholars have found that morphine has a protective effect on myocardial IRI, manifested as myocardial systolic function improved infarct size, reduced mortality [1]. 1 The main mechanism of IRI 1.1 Oxygen free radicals increase found [2], xanthine oxidase (xanthine oxidase, XO) system is reactive oxygen species during ischemia / reperfusion