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目的观察胰岛素强化治疗对2型糖尿病(T2DM)患者静息能量消耗(REE)的影响。方法对26例T2DM患者经胰岛素强化治疗前后的临床生化指标、炎症因子及REE进行比较分析。结果胰岛素强化治疗能显著降低REE,用体重(Wt)校正后REE/Wt下降约10.4%(P=0.006)。多元回归分析提示REE与FPG、高敏C反应蛋白(hsC-RP)、白介素6(IL-6)正相关(P<0.05)。结论胰岛素强化治疗可降低T2DM患者的REE,REE的降低与血糖下降及炎症反应的改善相关。
Objective To investigate the effect of intensive insulin therapy on resting energy expenditure (REE) in type 2 diabetes mellitus (T2DM). Methods The clinical and biochemical indexes, inflammatory factors and REE in 26 T2DM patients before and after intensive insulin therapy were compared. Results Intensive insulin treatment significantly reduced REE, with a decrease of approximately 10.4% in REE / Wt after weight-corrected (Wt) (P = 0.006). Multivariate regression analysis showed that REE was positively correlated with FPG, hsC-RP and IL-6 (P <0.05). Conclusion Intensive insulin therapy can reduce the REE in T2DM patients. The decrease of REE is associated with the decline of blood glucose and the improvement of inflammatory response.