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目的 :探讨六味地黄发酵液的抗肿瘤和对化疗药物的减毒作用。方法 :采用小鼠腋下接种肿瘤细胞法观察抗肿瘤作用 ,采用环磷酰胺法造成白细胞减少 ,观察六味地黄发酵液对外周血白细胞数的影响。结果 :六味地黄发酵液对小鼠肝癌H2 2 的生长具有显著抑制作用 (P <0 .0 5) ,而六味地黄煎剂无明显抑瘤作用 ;六味地黄发酵液和六味地黄煎剂对环磷酰胺造成的小鼠骨髓抑制 ,均有升高外周血白细胞的作用 (P <0 .0 1 )。结论 :六味地黄发酵液有抗肿瘤及减低化疗所致造血系统毒性作用
Objective: To explore the anti-tumor effect of Liuwei Dihuang fermentation broth and its attenuation effect on chemotherapeutic drugs. Methods : Antitumor effect was observed by inoculation of tumor cells with the mouse axilla. Cyclophosphamide was used to induce leukopenia and the effect of Liuwei Dihuang fermentation broth on peripheral blood leukocyte number was observed. RESULTS: The fermentation of Liuwei Dihuang had a significant inhibitory effect on the growth of hepatocarcinoma H2 2 in mice (P < 0.05), while Liuwei Dihuang Decoction had no significant anti-tumor effect; Liuwei Dihuang fermentation broth and Liu Wei Di Huang Decoction to cyclophosphophosphate. Amyloid-induced bone marrow suppression in mice increased the peripheral blood leukocytes (P < 0.01). Conclusion : Liuwei Dihuang fermentation broth has anti-tumor effect and reduces the toxicity of hematopoietic system caused by chemotherapy