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目的探讨聚天冬氨酸新型改性产品天冬氨酸-谷氨酸共聚物(PAG)的生物降解性及毒性。方法取受纳水体的水为接种水,采用CO2法对浓度为98.8 mg/L PAG的可生物降解性进行研究;观察PAG灌胃染毒对SPF级昆明小鼠的急性毒性和骨髓嗜多染红细胞微核率;以5、1、0.2、0.04和0.008 mg/皿的剂量进行PAG对TA97、TA98、TA100、TA102菌株的Ames试验;观察100、500和1 000 mg/L浓度PAG对小麦及大豆种子发芽率的影响。结果 PAG的10 d和28 d生物降解率分别为34%和79%,属于易生物降解物质;小鼠经口半致死量(LD50)大于10 000 mg/kg;Ames试验结果呈阴性;PAG对植物生长发育无明显不良影响。结论 PAG为实际无毒且非致突变性的安全化学品。
Objective To investigate the biodegradability and toxicity of aspartic acid-glutamic acid copolymer (PAG), a new modified polyaspartic acid product. Methods The water of receiving water was used as inoculation water. The biodegradability of PAG with the concentration of 98.8 mg / L was studied by CO2 method. The acute toxicity and bone marrow polyphagous Micronucleus rate of erythrocytes; Ames test of PAG on TA97, TA98, TA100 and TA102 strains at the doses of 5, 1, 0.2, 0.04 and 0.008 mg / Effect of soybean seed germination rate. Results The biodegradation rates of PAG were 34% and 79% on the 10th and 28th days respectively, which were easily biodegradable. The LD50 of the mice was more than 10 000 mg / kg. The results of Ames test were negative. No significant adverse effects on plant growth and development. Conclusion PAG is a virtually non-toxic and non-mutagenic safety chemical.