目的 探讨对于脑梗死患者使用氟哌噻吨美利曲辛联合右佐匹克隆治疗的效果，并分析其对于患者的不良心理反应以及临床症状的效果?方法 选取我院在2019年5月至2021年5月所接收和治疗的脑梗死患者共80例作为此次研究对象，将其按照随机数表法分为两组，每组40例，分别为联合组和单一组?其中单一组主要对患者使用氟哌噻吨美利曲辛治疗，联合组则在单一组的基础上联合右佐匹克隆治疗?对比两组患者的治疗效果?结果 联合组的HAMA?HAMD以及PSQI评分分别为(15.12±1.08)?(17.17±0.28)以及(6.49“,”Objective To study the effect of flupentixol， melitracen and dexzopiclone on patients with cerebral infarction， and to analyze its adverse psychological reactions and clinical symptoms. Methods A total of 80 patients with cerebral infarction received and treated in our hospital from May 2019 to May 2021 were selected as the research object. Then they were randomly divided into two groups with 40 cases in each group， namely the combined group and the single group. The single group was mainly treated with flupentixol and melitracen， while the combined group was treated with dexzopiclone on the basis of the single group. After that， the therapeutic effects of the two groups were compared. Results According to the comparison， the scores of HAMA， HAMD and PSQI in the combined group were (15.12±1.08)， (17.17±0.28) and (6.49±2.01) respectively， which were lower than (21.05±1.05)， (22.18±1.16) and (9.09±1.95) in the single group (t =24.898， 26.552 and 5.871， P <0.05). The total effective rate of the combined group was 92.50%， which was significantly higher than 62.50% of the single group (χ^2=7.469， P <0.05). The complication rate of the combined group was significantly lower than that of the single group， and the difference was statistically significant (χ^2=6.102， P <0.05). Conclusion For cerebral infarction patients with negative emotions such as anxiety and depression， flupentixol， melitracen combined with dexzopiclone has significant clinical efficacy， is conducive to alleviate clinical symptoms and has good safety.