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结构与苯安定(BZD)不同的化合物,在神经组织中总能与BZD)受体结合,二黄酮类3＇,8＇-双-4＇,5,7-三羟基黄酮(biflavonoid a-mentoflavonc)就是其中之一,作者曾对具镇静药用价值的11种无花植物及3种有花植物进行筛选,发现其中含有BZD受体及其它受休的配体,作者对西番莲Passiflora coeruleaL.进行了深入研究,从中分离纯化出5,7-二羟黄酮(chrysin),并在离体动物实验中证实chrysin对中枢BZD受体有较高的亲和力,而外周BZD受体的亲和力其小;在体动物实验
The compounds with different structure and benzene azadirachtin (BZD) can always bind to BZD receptors in nerve tissue, and the biflavonoid a-ment of flavonoid (3 ’, 8’-bis-4’ ) Is one of them. The authors screened 11 species of flowering plants and 3 species of flowering plants with sedative medicinal value and found that they contained BZD receptors and other receptor ligands. Passiflora coeruleaL .In this paper, chrysin was isolated and purified from chrysin, and Chrysin was found to have high affinity to the central BZD receptor in ex vivo animal experiments, while the affinity of peripheral BZD receptor was small In vivo experiments