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目的 比较口服及阴道用米索前列醇对晚期妊娠促宫颈成熟和引产的效果。方法 选择有引产指征、无引产及米索前列醇使用禁忌症的单胎、头位、胎膜完整的晚期妊娠妇女 2 0 0例 ,随机分为A组 ,米索前列醇 5 0 μg口服和B组 ,米索前列醇 2 5 μg阴道给药各 10 0例。间隔 4h时重复给药 ,宫颈成熟 (Bishop评分≥ 6分 )或临产后停止用药 ,最大剂量 6次 ,未临产者静滴催产素。结果 2 4h内经阴道分娩A组 31例 ,B组 47例 ,从引产开始至阴道分娩时间A组 35 .6± 12 .1h ,B组 2 8.2± 14.1h(P <0 .0 5 )。两组剖宫产率、异常子宫收缩、产时并发症的发生率及新生儿出生情况无显著差异。结论 米索前列醇 5 0 μg口服用于晚期妊娠促宫颈成熟和引产 ,给药方便 ,副作用较小。
Objective To compare the effects of oral and vaginal misoprostol on cervical ripening and induction of labor during late pregnancy. Methods Totally 200 pregnant women with single fetus, head position and complete fetal membranes without induced abortion and misoprostol misoprostol were randomly divided into group A and misoprostol 50 μg orally And B group, misoprostol 25 μg vaginal administration of 100 cases. Intermittent 4h repeated administration, cervical maturation (Bishop score ≥ 6 points) or discontinued after treatment, the maximum dose of 6 times, no infusion intravenous oxytocin. Results In vaginal delivery within 24 hours, 31 cases were in group A and 47 cases in group B. The time from induction of labor to vaginal delivery was 35.6 ± 12.1 hours in group B and 8.2 ± 14.1 hours in group B (P <0.05). Cesarean section rate, abnormal uterine contractions, the incidence of complications during labor and neonatal birth no significant difference. Conclusions Misoprostol (50 μg) is used orally to induce cervical ripening and induction of labor in late pregnancy, with convenient administration and less side effects.