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验证慢性阻塞性肺疾病（ＣＯＰＤ）急性加重期，Ｃ反应蛋白（ＣＲＰ）作为观察指标的价值一方法ＣＯＰＤ急性加重期患者４Ｄ例，均为抗生素治疗有效且中途未换用其它抗生素。人院后ｄ１。３、５、７、１４分别检测ＣＲＰ、ＷＢＣ、ＥＳＲ，人院时及人院后ｄ７、１４摄Ｘ线胸片，同时观察日最高体温和咳嗽频率、难度、痰粘度及肺部体征。结果人院时ＣＲＰ均＞８．０ｍｇ／Ｌ，阳性率为１００％，与ＷＢＣ、ＥＳＲ．Ｔ的阳性率相比差异有显著性（Ｐ＜０．０１或Ｐ＜０．０５），ＣＲＰ在ｄ１、３、５、７、１４天时分别为６３．８±２０．２、４２．０±１４．０、２３６±７．１、１０．７±３．５、３．１±０．７ｍｇ／Ｌ，峰值在第１天，随炎症好转ＣＲＰ逐渐下降，ＣＲＰ的变化与日最高体温的变化有良好相关性（ｒ＝０．７１Ｐ＜０．０５），与其它观察指标无相关性（Ｐ＞０．０５）。结论ＣＲＩ，在ＣＯＰＤ急性加重期是一个良好的观察指标，可反映抗生素的即时疗效，比ＷＢＣ、ＥＳＲ更迅速且敏感，与日最高体温变化有较好的相关性。
Validation of acute exacerbation of chronic obstructive pulmonary disease (COPD), C-reactive protein (CRP) as an indicator of the value of a method in patients with acute exacerbations of COPD 4D cases, are antibiotic treatment is effective and did not switch to other antibiotics. After hospital d1.3, 5,7,14 were detected CRP, WBC, ESR, hospital and post-hospital d7,14 ray X-ray, while observed the highest body temperature and cough frequency, difficulty, sputum viscosity and Pulmonary signs. Results When hospitalized CRP were> 8.0mg / L, the positive rate was 100%, and WBC, ESR. T (P <0.01 or P <0.05). The CRP was 63.8 ± 20.2 and 4.02.0 ± d on d 1, 3, 5, 7 and 14 days respectively 14.0,236 ± 7.1,10.7 ± 3.5,3.1 ± 0.7mg / L, the peak on the first day, with the improvement of CRP CRP gradually decreased, changes in CRP and daily maximum body temperature changes There was a good correlation (r = 0.71P <0.05), no correlation with other indicators (P> 0.05). Conclusions CRI is a good indicator in acute exacerbation of COPD. It can reflect the immediate curative effect of antibiotics. It is more rapid and sensitive than WBC and ESR, and has a good correlation with the change of daily maximum body temperature.