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目的探讨闪光视觉诱发电位(flash visual evoked potentials,FVEP)在新生儿重症监护病房的应用及相关因素分析,为早产儿视功能诊断提供科学依据。方法收集新生儿重症监护病房早产儿30例作为实验组,该组患儿常合并两种或多种高危因素,普通新生儿病房足月新生儿30例作为对照组,均排除致脑损伤高危因素的普通病种住院患儿。两组患儿均在入院后1~2周行FVEP检查,对异常者,在生后3个月、6个月进行了随访。结果胎龄与P100潜伏期密切相关,表现为胎龄越小,P100潜伏期越延长,差异有高度统计学意义(P<0.001),而引起P100主波缺失的主要高危因素是高胆红素血症、窒息、甲状腺功能减退。对FVEP异常者随访发现,在16例(26眼)早产儿FVEP异常者中,有8例早产儿恢复正常,1例无改变,7例失访。足月儿组中,FVEP4例(6眼)异常,6个月后随访,P100潜伏期均已恢复同龄参考水平。结论 FVEP检查为早产儿视功能状态提供一种准确、灵敏、重复性好的客观检测方法。高胆红素血症、窒息、甲状腺功能减退等是引起早产儿脑损伤不可忽视的高危因素。
Objective To investigate the application and related factors analysis of flash visual evoked potentials (FVEP) in neonatal intensive care unit and to provide a scientific basis for visual function diagnosis of premature infants. Methods Thirty newborns with preterm infants in the intensive care unit of the neonatal intensive care unit were enrolled in this study. Two or more high risk factors were included in the neonatal intensive care unit. Thirty newborns with full-term neonatal ward as control group were excluded from the risk factors for brain injury The common disease hospitalized children. FVEP was performed in both groups 1 to 2 weeks after admission, and abnormalities were followed up 3 months and 6 months after birth. Results The gestational age was closely related to the P100 latency. The smaller the gestational age, the longer the P100 latency, the difference was highly statistically significant (P <0.001). The main risk factor of the P100 main wave deletion was hyperbilirubinemia , Suffocation, hypothyroidism. Follow-up of abnormalities of FVEP found that in 16 (26 eyes) of premature infants with abnormal FVEP, 8 of them returned to normal, 1 had no change and 7 had no follow-up. Full-term infants, FVEP 4 cases (6 eyes) abnormalities, follow-up after 6 months, P100 latency have been restored to the same age reference level. Conclusion FVEP examination provides an objective, accurate, sensitive and reproducible method for the detection of preoperative functional status. Hyperbilirubinemia, asphyxia and hypothyroidism are the risk factors that can not be ignored in premature infants with brain injury.