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目的探讨近端胃切除和全胃切除对术后辅助化疗耐受性及完成率的影响。方法选择接受近端胃切除术的胃上部癌患者50例设为甲组,选择同期接受全胃切除术的胃上部癌患者50例设为乙组,回顾性分析患者的临床治疗,观察并记录两组的不良反应以及6次化疗完成情况。结果两组血液学毒性发生率比较,差异无统计学意义(P>0.05);两组消化道反应发生率比较,差异有统计学意义(P<0.05);甲组不良反应发生率(48.0%)明显高于乙组(18.0%)(P<0.05)。甲组消化道反应发生率明显高于血液学毒性发生率(P<0.05)。甲组完成率明显低于乙组,比较差异具有统计学意义(P<0.05)。结论对胃上部癌患者行近端胃切除术会降低患者的辅助化疗耐受性和6次化疗完成率,该术式是否合理值得进一步研究。
Objective To investigate the effect of proximal gastrectomy and total gastrectomy on postoperative adjuvant chemotherapy tolerance and completion rate. Methods Fifty patients with upper gastric cancer undergoing proximal gastrectomy were selected as group A. Fifty patients with upper gastric cancer undergoing total gastrectomy during the same period were enrolled as group B. The clinical treatment, observation and record of the patients were retrospectively analyzed Adverse reactions in both groups and 6 completed chemotherapy. Results There was no significant difference in the incidence of hematological toxicity between the two groups (P> 0.05). The incidence of digestive tract reaction was significantly different between the two groups (P <0.05). The incidence of adverse reactions in group A (48.0% ) Was significantly higher than that of group B (18.0%) (P <0.05). Group A gastrointestinal reaction was significantly higher than the incidence of hematological toxicity (P <0.05). Group A completion rate was significantly lower than Group B, the difference was statistically significant (P <0.05). Conclusion proximal gastrectomy in patients with upper gastric cancer will reduce the patient’s adjuvant chemotherapy tolerance and the completion rate of 6 chemotherapy, the operation is reasonable and worthy of further study.