人胚胎早期死亡率很高(60%～70%),主要原因是胚胎植入时出现错误。同样,将成功实现体外受精的胚胎移入母体后无法实现妊娠,其主要原因可能也是植入过程障碍(约85%)。植入过程是两个基因构成不同的个体:母体和胎儿在免疫学上一次成功的相互作用,而母儿HLA抗原之间的差异曾被认为是有害的,但近期大量资料显示,这种差异不仅无害,而且对胚胎植入和维持妊娠十分有利。在啮齿动物进行的试验也表明在MHC区域中的一些基因对胚胎的植入、存活和生长起重要作用。为了解HLA系 Early human embryo mortality is high (60% to 70%), mainly due to errors in embryo implantation. Similarly, pregnancy after in vitro fertilization of the embryo into the mother can not be achieved, the main reason may be impaired in the process of implantation (about 85%). Implantation is a process in which two genes make up a different entity: a successful immunocompromised interaction between the mother and the fetus, and differences between mother and child HLA antigens have been considered detrimental, but recent data show that such differences Not only harmless, but also beneficial for embryo implantation and maintenance of pregnancy. Experiments in rodents have also shown that some genes in the MHC region play an important role in embryo implantation, survival and growth. To understand HLA lines