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采用体外大鼠肝微粒体系统和体内经饮水加氟（１５０ｍｇ／Ｌ），同时给予β－胡萝卜素的实验研究方法，研究抗氧化剂β－胡萝卜素对氟所致脂质过氧化作用的影响。体外实验结果表明，加氟可使微粒体系统脂质过氧化物（ＬＰＯ）含量显著增加（Ｐ＜０．０１），同时加入β－胡萝卜素可拮抗氟致微粒体系统的脂质过氧化作用；体内实验结果表明，饮水加氟（１５０ｍｇ／Ｌ）可使大鼠血清、肝、肾组织中ＬＰＯ含量显著增加（Ｐ＜０．０１）；全血及心、肝、肾组织谷胱甘肽（ＧＳＨ）含量明显下降（Ｐ＜０．０１）；全血、肾组织中谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）含量明显下降（Ｐ＜０．０１）；饮氟水同时给予β－胡萝卜素可拮抗上述作用。
In vitro rat liver microsomes and in vivo drinking water fluoride (150mg / L), while the experimental method of β-carotene to study the antioxidant effects of β-carotene on fluoride-induced lipid peroxidation. The results of in vitro experiments showed that fluoride addition significantly increased the content of lipid peroxides (LPO) in the microsomal system (P <0.01), and the addition of β-carotene could antagonize the lipid peroxidation induced by fluoride-induced microsomes ; In vivo experiments showed that drinking water fluoride (150mg / L) can significantly increase the serum LPO content in rat liver, liver and kidney (P <0.01); whole blood and heart, liver, kidney tissue glutathione (P <0.01). The content of GSH-Px in whole blood and kidney decreased significantly (P <0.01) Carotene can antagonize the above effects.