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To the Editor:We have enjoyed reading the work of Chen et al.[1] which investigated the diagnostic value of circulating (peripheral blood) endometrial cells (CECs) for endometriosis.By modifying their detection technique,Chen et al.[1] have demonstrated a high detection rate of CECs in the endometriosis group compared to the control group (P ＜ 0.001)with high sensitivity (89.5％) and specificity (87.5％) that was independent of menstrual cycle phases.The authors concluded that CEC may be a promising biomarker for endometriosis for the development of a noninvasive diagnostic assay,but these findings require validation in a larger,multicenter study population.