用[~3H]PK11195和[~3H]氟硝西沣比较了外周型苯二氮(艹卓)(PBR)结合部位在大鼠各组织中的相对密度。结果表明,血小板为研究外周型结合部位的较好模型。以完整血小板为模型,观察了PBR结合部位的性质及温度对结合性质的影响。结果证实,这种结合部位具有饱和性、专一性、可逆性以及较高的亲和力,温度对配体的亲和力有明显的影响。 The relative density of peripheral benzodiazepine (PBR) binding sites in each tissue of rats was compared with [~ 3H] PK11195 and [~ 3H] flunitrazepam. The results show that platelet is a better model for studying peripheral binding sites. With the intact platelet as a model, the nature of PBR binding sites and the effect of temperature on the binding properties were observed. The results confirmed that this binding site with saturation, specificity, reversibility and high affinity, the temperature of the ligand affinity has a significant impact.