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目的:观察OLF[O:草酸铂(L-OHP);L:醛氢叶酸(LV);F:氟尿嘧啶(5-Fu)]方案联合羟基喜树碱(HCPT)腹腔灌注热化疗治疗晚期胆系肿瘤的近期疗效。方法:24例晚期胆系肿瘤患者采用OLF方案静脉化疗:L-OHP 85 mg/m2,CF 130 mg/m2静脉滴注2 h,第1、8天给药;5-Fu 200 mg/m2快速静脉滴注30 min,后给予5-Fu 1 000 mg/m2静脉泵入22 h,第1、8天给药。静脉化疗间歇期配合HCPT 15 mg腹腔灌注化疗,静脉化疗和腹腔化疗时均辅以热疗。28 d为1个周期,按RECIST评价疗效,同时综合评估临床受益反应指标:疼痛、体力状况及体重变化。结果:24例患者均化疗2个周期以上,其中完全缓解0例,部分缓解7例(29.2%),稳定8例(33.3%)。16例(66.7%)患者临床获益,生活质量提高。不良反应主要为骨髓抑制和消化道反应。结论:OLF方案联合HCPT腹腔灌注热化疗治疗晚期胆系肿瘤具有较好的近期疗效,不良反应能耐受,值得进一步研究。
OBJECTIVE: To observe the effect of OLF [O: oxaliplatin (L-OHP); L: aldofen (LV); F: fluorouracil The recent efficacy of cancer. Methods: Twenty-four patients with advanced cholangiocarcinoma undergoing OLF regimen were treated with intravenous infusion of L-OHP 85 mg / m 2 and CF 130 mg / m 2 for 2 h on days 1 and 8, and 5-Fu 200 mg / m 2 After intravenous infusion for 30 min, 5-Fu 1 000 mg / m2 was given intravenously for 22 h and administered on days 1 and 8. Intermittent intravenous chemotherapy with HCPT 15 mg peritoneal perfusion chemotherapy, intravenous chemotherapy and intraperitoneal chemotherapy are supplemented by hyperthermia. 28 days for a period of 1, according to RECIST evaluation of efficacy, and comprehensive evaluation of clinical benefit response indicators: pain, physical status and weight changes. Results: All of the 24 patients were treated with more than 2 cycles of chemotherapy, including 0 complete remission, 7 partial remission (29.2%) and 8 stable (33.3%) remission. Sixteen patients (66.7%) had clinical benefits and improved quality of life. Adverse reactions are mainly myelosuppression and gastrointestinal reactions. CONCLUSION: OLF combined with HCPT intraperitoneal perfusion thermochemotherapy has good curative effect in the treatment of advanced cholangiocarcinoma. Adverse reaction is worthy of further study.