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恒河猴脾脏和淋巴结经葡聚糖凝胶 G25(200—400目)层析制备的 TF_M 样物质,单独或联合治疗3类风湿性关节炎病人15例,2例轻型患者获得显著疗效,其余13例有效。重症肌无力9例,显效者2例,好转者4例,无效者3例。白塞氏综合症1例获得显著疗效。讨论了 TF_M 样物质治疗自身免疫病有效的可能原因。
TFM-like substances prepared by chromatography on dextran gel G25 (200-400 mesh) in rhesus monkey spleen and lymph nodes were treated individually or in combination with 15 patients with 3 rheumatoid arthritis and 2 patients with mild type of disease. The remaining 13 cases effective. Myasthenia gravis in 9 cases, markedly in 2 cases, improved in 4 cases, 3 cases were ineffective. Behcet’s syndrome in 1 case achieved a significant effect. The possible reasons why TF_M-like substances are effective in the treatment of autoimmune diseases are discussed.