本文简述了近年来利用自身免疫病动物模型进行人工特异免疫调节方法的研究概况，包括ＣＤ４￣＋Ｔ细胞亚群的偏离与纠正、辅助刺激分子的阻断、ＴＣＲ拮抗剂、口服自身抗原诱导自身免疫耐受和ＴＣＲ多肽疫苗等方法，阐述了这些调节方法的机理及特点等。了解这些特异的免疫调节方法对于探索特异治疗人类自身免疫病的途径将有所帮助。 This article summarizes the research progress of artificial immunosuppression using animal models of autoimmune diseases in recent years, including the deviations and corrections of CD4 ~ + T cell subsets, the blockade of accessory stimuli, the induction of TCR antagonists and oral self-antigens Immune tolerance and TCR peptide vaccine and other methods, described the mechanism of these regulatory methods and characteristics. Understanding these specific immunomodulatory methods will be helpful in exploring ways to specifically treat human autoimmune diseases.