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目的观察美金刚联合奥卡西平对术后幻肢痛的疗效。方法对骨科20例高位截肢后出现幻肢痛的住院患者口服美金刚联合奥卡西平治疗，观察不同时间疼痛持续时间、程度及药物不良反应。结果10例患者服药1w后临床症状明显缓解，10例患者2w时症状明显减轻。16例患者服药后未有不良反应主诉，2例服药初期有轻度头昏，2例轻度恶心，均未停药，对症处理后缓解。治疗14d末检查血常规、肝功能、肾功能未见异常。结论美金刚联合奥卡西平治疗术后幻肢痛安全有效。“,”Objective To observe the ef ect of Memantine and Oxcarbazepine for phantom limb pain after surgery. Methods 20 inpatient after high level of amputation were treated with various oral doses of Memantine and Oxcarbazepine. Pain-persist during ,pain severity and drug adverse reaction were observed in various time points. Results In half of 20 patients pain relieved completely after 1 week treatment, the other improved obviously in 2 weeks. 16 patients complained of no discomfort, 2 patients had mild dizziness , 2 patients had mild nausea. Al patients remained therapy and had normal routine blood test, liver function and renal function in the end of 14-day-admininstration. Conclusion Memantine and Oxcarbazepine treats phantom limb pain after surgery ef ectly and safely.