论文部分内容阅读
血管扩张剂用于治疗顽固性心力衰竭,日益增多。口服哌唑嗪有类似硝普钠的作用,可均衡地降低前、后负荷,提高心排出量(Co),降低左室充盈压(LVFP)。近来一些作者报道,连续用哌唑嗪可使其药效减小。为了澄清这个问题,二文均观察了哌唑嗪长程治疗的血液动力学效应。Feldman 对13例严重充血性心力衰竭在服用洋地黄和速尿的过程中,加用了哌唑嗪。于服“首次剂量”、“滴定剂量”[从首次剂量2mg 逐渐增加剂量,直至心排出量不再增加,肺动脉舒张压(PAD)不再下降或平均动脉压(MAP)下降>10毫米汞柱,此时的剂量为滴定剂量,一般为2～5mg,每6～
Vasodilators for the treatment of refractory heart failure, increasing. Oral prazosin has a similar effect of sodium nitroprusside can be balanced to reduce the load before and after, improve cardiac output (Co), reduce left ventricular filling pressure (LVFP). Recently, some authors have reported that prazosin in a row can reduce its efficacy. To clarify this issue, both papers examined the hemodynamic effects of long-term prazosin treatment. Feldman added prazosin to 13 cases of severe congestive heart failure while taking digitalis and furosemide. In the “first dose”, “titration dose” [from the first dose of 2mg gradually increased dose until cardiac output no longer increases, pulmonary artery diastolic pressure (PAD) no longer decreased or mean arterial pressure (MAP) decreased> 10 mmHg , The dose at this time titration dose, usually 2 ~ 5mg, every 6 ~