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目的纯化处理处方剂量较大的芪桂消癥颗粒。方法用乙醇沉淀法和壳聚糖对芪桂消癥颗粒进行了纯化效果的比较。考察指标为总固体物、黄芪总皂苷和多糖的含量。结果两种纯化工艺效果相近,均使制剂总固体物的含量明显减少,但乙醇沉淀法使多糖含量显著降低,壳聚糖则对黄芪总皂苷和多糖的含量影响较小。结论采用壳聚糖除杂质效果较好,制剂工艺稳定。
Objective To purify and treat the prescription of Qigu Guixiao Granules. Methods ethanol precipitation and chitosan on the purification of Qi Guixia particles were compared. Study indicators for the total solids, total astragalus content and polysaccharides. Results The results of the two purification processes were similar, which all significantly reduced the total solid content of the preparation. However, the ethanol precipitation method significantly reduced the content of polysaccharide, while the chitosan had little effect on the content of total saponin and polysaccharide of Astragalus. Conclusion The removal of impurities by chitosan is better and the preparation process is stable.