A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determina-tion of the synthesized compounds was carried out using spectroscopic techniques including IR, 1H NMR, and mass spectrometry.Structural effects on reactivity were also studied.