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目的:探讨自然流产与染色体核型异常的关系。方法:培养淋巴细胞,常规收获制片,G显带处理。对3 076例有自然流产史的患者进行染色体核型分析。结果:染色体异常者128例,占4.16%,其中平衡易位63例,罗氏易位39例,臂间倒位26例。流产1～6次染色体异常检出率分别为3.17%、3.23%、5.81%、4.76%、10.29%、8.82%,流产3次以上明显增加。结论:在自然流产患者检出的异常染色体中,以染色体易位为主要类型。染色体异常检出率随着自然流产次数的增加而升高,且呈明显正相关。
Objective: To explore the relationship between spontaneous abortion and chromosomal abnormalities. Methods: Lymphocytes were cultured, harvested routinely and treated with G - banding. Karyotype analysis of 3 076 patients with a history of spontaneous abortion. Results: 128 cases of chromosomal abnormalities, accounting for 4.16%, of which 63 cases of balanced translocation, Roche translocation in 39 cases, arm inversion in 26 cases. Abortion 1 to 6 chromosomal abnormalities were 3.17%, 3.23%, 5.81%, 4.76%, 10.29%, 8.82%, abortion more than 3 times increased significantly. Conclusion: Chromosomal translocation is the main type of abnormal chromosomes detected in spontaneous abortion patients. The detection rate of chromosomal abnormality increased with the increase of the number of spontaneous abortion, and showed a significant positive correlation.