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目的:了解类风湿关节炎与细胞凋亡的研究进展,以期发现相互之间的关系及其变化规律,探讨类风湿关节炎细胞凋亡特征。资料来源:应用计算机检索1995-01/2003-12Medline和国家科技图书文献中心外文库与类风湿关节炎及细胞凋亡相关的文章,检索词为“rheumatoidarthritis,apoptosis”,限定文章语种为英文。计算机检索1995-01/2003-12重庆维普中文科技期刊数据库、清华同方中文科技期刊数据库和中国生物医学文献光盘数据库关于类风湿性关节炎与细胞凋亡相关的文章,限定文章语种为中文,检索词为“类风湿关节炎,细胞凋亡,舌象”。资料选择:对资料进行初审,选取类风湿关节炎与细胞凋亡相关性研究的文献开始查找全文。纳入标准:①类风湿关节炎与细胞凋亡的实验研究。②类风湿关节炎与细胞凋亡的临床研究。③中医舌象与细胞凋亡的研究。排除标准:重复性研究。资料提炼:共收集到82篇关于类风湿关节炎与细胞凋亡研究的文章,13篇符合纳入标准。排除的69篇文章中,58篇为重复性研究,11篇为综述类文章。资料综合:13篇文献中有11篇文献是通过实验研究和临床研究,从关节滑膜、外周血检测中发现类风湿关节炎存在着细胞凋亡异常,提示类风湿关节炎的发病、药物和物理治疗的实质均与滑膜细胞凋亡有关。余2篇是其他疾病舌象的细胞凋亡研究,揭示舌象细胞凋亡与疾病的病理相关,目前未找到有关类风湿关节炎舌象与细胞凋亡的有关报道,说明中医舌象与细胞凋亡的相关性研究存在许多空白。结论:中西医结合治疗类风湿关节炎具有优越性,从文献资料显示目前治疗类风湿关节炎的方法,可能通过影响类风湿关节炎的细胞凋亡而发挥作用。中医证型与细胞凋亡的研究仅限于少数的一两个病种,而舌象为证的重要诊断部分,故类风湿关节炎证(或舌象)细胞凋亡的内在联系有待研究,以进一步揭示类风湿性关节炎证的本质、舌象形成的机制。
OBJECTIVE: To understand the research progress of rheumatoid arthritis and apoptosis in order to find out the relationship between them and their changing rules and to explore the characteristics of apoptosis in rheumatoid arthritis. DATA SOURCES: The articles related to rheumatoid arthritis and apoptosis were searched from Medline and the National Library of Science and Technology from January 1995 to December 2003 with the search term of “rheumatoid arthritis, apoptosis” and the limited article language is English. A computer-based online search of Chongqing VIP Chinese Science and Technology Periodical Database, Tsinghua Tongfang Chinese Science and Technology Periodical Database, and Chinese Biomedical Literature CD-ROM database for articles related to rheumatoid arthritis and apoptosis from January 1995 to December 2003 were searched by computer. The word “rheumatoid arthritis, apoptosis, tongue.” Data selection: the first instance of the data, select rheumatoid arthritis and apoptosis related literature began to find the full text. Inclusion criteria: ① experimental study of rheumatoid arthritis and apoptosis. ② clinical research of rheumatoid arthritis and apoptosis. ③ tongue and apoptosis in traditional Chinese medicine research. Exclusion criteria: Repeatability study. DATA EXTRACTION: A total of 82 articles on rheumatoid arthritis and apoptosis were collected and 13 met the inclusion criteria. Of the 69 articles excluded, 58 were repetitive studies and 11 were review articles. DATA SYNTHESIS: Eleven literatures in thirteen articles, through experimental research and clinical research, found abnormal apoptosis in rheumatoid arthritis from synovial synovium and peripheral blood, which indicated that the incidence of rheumatoid arthritis The essence of physical therapy and synovial cell apoptosis. The remaining 2 articles are studies on the apoptosis of tongue in other diseases, revealing that tongue-like cell apoptosis is related to the pathology of the disease. Currently, no reports on the tongue and apoptosis of rheumatoid arthritis have been found, There are many gaps in the study of apoptosis. Conclusion: The treatment of rheumatoid arthritis with integrated traditional Chinese and western medicine is superior. The literature shows that the current treatment of rheumatoid arthritis may affect the apoptosis of rheumatoid arthritis. TCM syndromes and apoptosis research is limited to a small number of one or two diseases, and the tongue as an important diagnostic part of the card, so rheumatoid arthritis (or tongue) apoptosis in the intrinsic link to be studied to To further reveal the nature of rheumatoid arthritis, tongue formation mechanism.