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用鹿茸醇提物对昆明系小鼠进行灌胃 ,剂量为 1 0g/ (kg·d) ,连续进行 10d ;然后 ,测定由环磷酰胺诱导的该小鼠骨髓嗜多染红细胞微核率 ;以探讨鹿茸醇提物对环磷酰胺所致小鼠遗传物质损伤是否具有保护作用。结果表明 ,鹿茸醇提物组(实验组 )小鼠骨髓嗜多染红细胞的微核率为 15 82± 0 2 2 ,而对照组为 2 4 2 3± 0 18,两组比较 ,差异非常显著 (P <0 0 1)。提示 ,鹿茸醇提物对环磷酰胺所致小鼠遗传物质损伤具有一定的保护作用
Kunming mice were intragastrically administered with ethanol extract of pilose antler at a dose of 10 g/(kg·d) for 10 days. Then, the micronucleus rate of bone marrow-derived polychromatic erythrocytes induced by cyclophosphamide was measured. To explore whether the alcohol extraction of pilose antler has protective effects on genetic damage of mice caused by cyclophosphamide. The results showed that the micronucleus rate of polychromatic erythrocytes in bone marrow of mice fed with antler alcohol extract group (experimental group) was 1582±0.22, while that of the control group was 542-23±18. The difference between the two groups was very significant. (P < 0 0 1). It is suggested that the antler extract has a protective effect on the damage of genetic material in mice induced by cyclophosphamide.