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目的探讨Peutz-Jeghers综合征(PJS)中Brg1蛋白的表达及其在PJS息肉发展过程中的作用。方法应用免疫组化法检测Brg1蛋白在72例PJS息肉组织、12例正常小肠黏膜组织、30例小肠癌组织中的表达,并探讨其与PJS息肉发生、发展及癌变的关系。结果 Brg1蛋白在小肠癌组中的阳性表达率为76.67%,PJS息肉组织为54.17%,正常小肠黏膜组织为16.67%;PJS息肉组和正常小肠黏膜组B rg1蛋白阳性表达差异有统计学意义(P<0.05);PJS息肉组和小肠癌组B rg1蛋白阳性表达差异有统计学意义(P<0.05)。结论 Brg1蛋白在小肠癌组织中存在过高表达,在PJS息肉组织中存在高表达,且可能是PJS息肉癌变的关键因子之一。
Objective To investigate the expression of Brg1 protein in Peutz-Jeghers syndrome (PJS) and its role in the development of PJS polyps. Methods The expression of Brg1 protein in 72 cases of PJS polyps, 12 cases of normal small intestinal mucosa and 30 cases of small intestine carcinoma was detected by immunohistochemistry and its relationship with the occurrence, development and carcinogenesis of PJS polyps. Results The positive rate of Brg1 protein in small intestine carcinoma was 76.67%, in PJS polyps was 54.17%, in normal small intestine mucosa was 16.67%. The positive expression of Brg1 in PJS polyps and normal small intestine mucosa was statistically significant ( P <0.05). The positive expression of Bgl protein in PJS polyps group and small intestine cancer group was statistically significant (P <0.05). Conclusion Brg1 protein is overexpressed in small intestinal cancer tissues and highly expressed in PJS polyp tissues, and may be one of the key factors in the carcinogenesis of PJS polyps.