论文部分内容阅读
目的:研究血管紧张素转换酶(ACE)基因多态性与脑卒中之间的相关性。方法:应用PCR技术,对98例脑血管疾病患者(分为脑血栓形成组、腔梗组和脑出血组)和52例对照组人群分别检测其基因频率和基因型频率。结果:D∶I等位基因比率脑卒中组为0.61∶0.39,对照组两者之比为0.43∶0.57,两组比较具有统计学差异(P<0.05),DD型基因两组相比差异也具有统计学意义(43/98vs10/52,P<0.05)。有高血压的脑卒中患者DD型基因及D等位基因频率较对照组增加(P<0.05),有、无脑卒中家族史患者DD型基因及D等位基因频率无明显改变(P>0.05)。结论:ACE基因I/D多态性是脑卒中特别是脑血栓及腔梗重要的危险因素,高血压病史与脑卒中患者ACEI/D多态性相关,而脑卒中家族史与之无关。
Objective: To investigate the association between angiotensin converting enzyme (ACE) gene polymorphism and stroke. Methods: 98 patients with cerebrovascular disease (divided into cerebral thrombosis group, lumen infarction group and cerebral hemorrhage group) and 52 controls were enrolled in this study. The gene frequency and genotype frequency were detected by PCR. Results: The ratio of D: I allele was 0.61: 0.39 in stroke group and 0.43: 0.57 in control group, with significant difference between the two groups (P <0.05) Statistically significant (43/98 vs 10/52, P <0.05). The frequency of DD genotype and D allele in stroke patients with hypertension was higher than that in control group (P <0.05). There was no significant change in DD genotypes and D allele frequency in stroke patients with family history of stroke (P> 0.05 ). CONCLUSION: ACE gene I / D polymorphism is an important risk factor for stroke, especially cerebral thrombosis and luminal infarction. The history of hypertension is associated with ACEI / D polymorphism in patients with stroke, while the family history of stroke has nothing to do with it.