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目的 了解发生三系病态造血的白血病主要类型 ,以及细胞数量与质量的变化与病情程度的关系。方法 观察16 8例常见白血病血象、骨髓象中的粒细胞系、红细胞系和巨核细胞系 ,进行质量与数量的分析统计和疗效的观察。结果 三系病态造血改变主要发生在急性粒细胞白血病 (AML ) ,其次是慢性粒细胞白血病 ;对 46例伴有病态造血与 2 6例非病态造血的 AML进行比较 ,前者贫血重、白细胞计数、外周血原始细胞较后者低 ,缓解率亦低 ,P均 <0 .0 1。结论 根据病态造血的程度可预测病情发展程度及缓解效果
Objective To understand the main types of leukemia in three-line pathological hematopoiesis and the relationship between the changes of cell number and quality and the severity of the disease. Methods 1680 cases of common leukemia blood, bone marrow in the granulocyte, erythrocyte and megakaryocyte lines, the quality and quantity of the statistical analysis and observation of the curative effect. Results The morbid hematopoietic changes of the three lines mainly occurred in acute myeloid leukemia (AML), followed by chronic myeloid leukemia. Comparing 46 cases of AML with morbid hematopoiesis and 26 cases of non-pathological hematopoiesis, the former had severe anemia, white blood cell count, Peripheral blood blast cells than the latter low, the response rate is also low, P <0.01. Conclusion According to the degree of pathological hematopoiesis, the extent of disease progression and the effect of remission can be predicted