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目的:探讨沙美特罗替卡松粉吸入剂对初入高海拔地区青年一氧化氮(NO)和一氧化氮合酶(NOS)的影响,为预防和治疗急性高原病提供新的措施。方法:将34名受试者随机分为沙美特罗组(n=18)和对照组(n=16),自海拔1400m历时5天进入5200m,从进入海拔5200m当天开始,沙美特罗组每天早晚各2次吸入沙美特罗替卡松粉1个剂量(沙美特罗50μg,丙酸氟替卡松100μg),对照组用同样的方法吸入喷完的沙美特罗替卡松粉吸入剂的空准纳器。第5天清晨空腹采肘静脉血检测一氧化氮(NO)、一氧化氮合酶(NOS)指标。结果:沙美特罗组较对照组NO增高,差异显著(P<0.05),NOS两组无显著性差异(P>0.05)。结论:吸入沙美特罗替卡松粉吸入剂可提高进驻高原者的抗氧化活力,改善高原低氧环境体内氧化与抗氧化之间的平衡紊乱。
Objective: To investigate the effects of salmeterol and fluticasone powder inhalers on the activity of nitric oxide (NO) and nitric oxide synthase (NOS) in young people at high altitudes, and to provide new measures for the prevention and treatment of acute altitude sickness. Methods: 34 subjects were randomly divided into salmeterol group (n = 18) and control group (n = 16). After 1400m altitude for 5 days, they entered 5200m. From the day of entering the altitude of 5200m, One dose (salmeterol 50 μg, fluticasone propionate 100 μg) was inhaled twice a day in the morning and evening, and the control group inhaled the blanket of inhaled salmeterol and fluticasone inhaler in the same manner Device. On the fifth day, blood samples of elbow venous blood were collected to measure nitric oxide (NO) and nitric oxide synthase (NOS) indicators. Results: NO in salmeterol group was significantly higher than that in control group (P <0.05). There was no significant difference between the two groups (P> 0.05). Conclusion: Inhaling salmeterol and fluticasone in inhalation can increase the anti-oxidant activity of those who entered the plateau and improve the balance between oxidation and anti-oxidation in plateau hypoxia.