Objectives To determine thechange of plasma leptin levels and the correlation be-tween hyperleptinaemia and insulin resistance orTNF -α in patients with congestive heart failure(CHF). Methods The levels of plasma leptin, fastingplasma insulin (FINS) and TNF-α in 64 male patientswith CHF and 30 healthy male people were measuredby ELISA. Body mass index (BMI), waist/hip ratio(WHR) and insulin resistance index (Homa-IR) werecalculated respectively. Results The plasma leptinlevels in CHF group were higher compared with con-trol group (P<0.00l). There was a increased trend ofplasma leptin levels in CHF group with the increaseof NYHA class (r_s=0.884, P<0.001), according to dif-ferent etiology,there was no significant difference ofplasma leptin levels in CHF group (P>0.05); FINS,Homa-IR and TNF-α levels in CHF group were high-er than in control group (all P<0.001); in CHF groupplasma leptin levels correlated with FINS (r=0.652, P<0.001),Homa-IR (r=0.561,P<0.001) and TNF-α (r=0.629,P<0.001); in multiple st Objectives To determine the change of plasma leptin levels and the correlation be-tween hyperleptinaemia and insulin resistance or TNF-α in patients with congestive heart failure (CHF). Methods The levels of plasma leptin, fasting plasma insulin (FINS) and TNF-α in 64 male Results Body plasma index (BMI), waist / hip ratio (WHR) and insulin resistance index (Homa-IR) werecalculated respectively. Results The plasma leptinlevels in CHF group were higher compared with con- There was a significant trend of plasma leptin levels in CHF group with the increase of NYHA class (r_s = 0.884, P <0.001), according to dif-ferent etiology, there was no significant difference of plasma leptin levels in CHF group (P> 0.05); FINS, Homa-IR and TNF-α levels in CHF group were high-er than in control group (all P <0.001); in CHF groupplasma leptin levels correlated with FINS P <0.001), Homa-IR (r = 0.561, P <0.001) and TNF-α 1); in multiple st