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目的探讨抗甲状腺药物致粒细胞缺乏症(粒缺)的临床特点。方法回顾性分析1994-01~2004-05北京中日友好医院收治的6例抗甲状腺药物致粒缺患者的临床资料。结果6例粒缺患者均为女性,年龄17~65岁,其中5例由他巴唑所致,1例丙基硫氧嘧啶所致,5例在服药后2个月内发生粒缺,1例在半年后发生。临床表现为突发高热咽痛。5例治愈,粒细胞在停药后2周内恢复,1例死亡。结论粒缺为严重的不良反应,不可预测,在甲亢患者开始药物治疗的2个月内,应高度警惕粒缺的发生。
Objective To investigate the clinical features of anti-thyroid drug agranulocytosis. Methods The clinical data of 6 patients with anti-thyroid drug induced nephrectomy admitted from Beijing Sino-Japanese Friendship Hospital from January 1994 to May 2004 were retrospectively analyzed. Results Six patients with granuloma were female, aged from 17 to 65 years. Five were caused by methimazole and one was treated with propylthiouracil. Five patients developed granulosis within two months after taking the drug Cases occurred in six months. Clinical manifestations of sudden high fever sore throat. 5 cases were cured, granulocytes recovered within 2 weeks after stopping, and 1 died. Conclusions Granuloma is a serious adverse reaction and unpredictable. Within 2 months after starting hyperthyroidism, vigilance should be highly observed.